New Study Shows Oxytocin Should be Refrigerated in Hot Climates

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On July 26, 2019, a study on the temperature stability of oxytocin was published in BMJ Open. The objective of the study was to compare the stability of oxytocin injection ampoules formulated for storage at ≤25°C with those labelled for refrigerated storage (2-8°C).

Some oxytocin products supplied to the global market are labelled for storage at ≤25°C, often with a shorter shelf-life relative to products labelled for refrigeration. Differences in labelled storage requirements can lead to uncertainties among stakeholders around the relative stability of oxytocin products and specifically whether ≤25°C products are more resistant to degradation.

When the accelerated studies were performed at 30°C, 40°C and 50°C, oxytocin ampoules formulated for non-refrigerated storage demonstrated comparable stability to those labelled for refrigerated storage and should not be interpreted by stakeholders as offering a more stable alternative.

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